TABLE 2

Localization of AGS proteins in the kidney

Summary of the localization of AGS family members within distinct segments of the normal kidney using immunohistochemistry. In studies with low staining, the cell types could not be determined.

ProteinAlternate NameGlomerulusProximal Convoluted TubuleThick Ascending LimbCollecting DuctPreglomerular Blood Vessels
AGS1RasD1/Dexras1+
AGS2Tctex1N/DN/DN/DN/DN/D
AGS3GPSM1a+
AGS4GPSM3/G18.1bN/DN/DN/DN/DN/D
AGS5GPSM2/LGN++
AGS6RGS12+++++
AGS7Trip13/PCH2/16E1-BP+
AGS8FNDC1/KIAA1866++
AGS9Rpn10/Psmd4N/DN/DN/DN/DN/D
AGS10GNAO+N/DN/DN/DN/D
AGS11TFE3bbb
AGS12TFEBbbb
AGS13MitFN/DN/DN/DN/DN/D
  • −, low to absent expression; +, detectable protein expression; N/D, not specifically determined.

  • a Detectable protein expression after ischemia-reperfusion injury.

  • b Low-to-undetectable levels for TFE3 and TFEB in the cytoplasm of renal tubules.