TABLE 3

Percent inhibition, relative to vehicle-treated animals, of ankle diameter, paw weight, and histopathology scores for VX-509 b.i.d. dose experiments

Using ANOVA plus Dunnett’s (measures) and Dunn’s (scored parameters) post hoc tests. n = 4 for naive control group, n = 5 for vehicle group, and n = 8 for all other treatment groups. Mean baseline values for the collagen + vehicle group are cumulative ankle diameter = 55.9 mm, paw weight = 2.2 g, ankle histopathology score = 10.6, knee histopathology score = 7.7. Control mean baseline values are cumulative ankle diameter = 45.7 mm, paw weight = 1.4 g, ankle histopathology score = 0, knee histopathology score = 0.

GroupDoseDosingJoint Measures, % Inhibition (±S.E.)Histopathology Score, % Inhibition (±S.E.)
Ankle DiameterPaw WeightAnkleKnee
mg/kg
Collagen + vehicleb.i.d.0 (±6.8)0 (±5)0 (±12.8)0 (±18.8)
Collagen + VX-50910b.i.d.55** (±10.3)65** (±12.8)59** (±23.4)81** (±30)
25b.i.d.70** (±5.5)80** (±8.5)70** (±12.8)98** (±6.5)
50b.i.d.76** (±3.4)93** (±5.5)81** (±5.3)100** (±0)
Collagen + etanercept10q.4.d.55** (±9.7)75** (±9.7)59** (±18.3)83** (±28.8)
control100**100**100**100**
  • ** P < 0.01 compared with CIA rats in the vehicle group.