TABLE 1

JAK3-dependent cell assays (n for each assay provided in the table)

AssayJAK Isoform DependencyIC50 ± S.D.n
nM
IL-2–stimulated HT-2 STAT-5 phosphorylationJAK399 ± 404
Mouse two-way MLRJAK3170 ± 1014
Human T-cell blast proliferationJAK3140, 4002
CD40L/IL-4–induced B-cell proliferationJAK3501