TABLE 2

Non-JAK3–dependent cell assays (n for each assay provided in the table)

AssayJAK Isoform DependencyIC50 ± S.D.n
nM
GM-CSF–stimulated TF-1 STAT-5 phosphorylationJAK22590 ± 16004
IFN-α–stimulated HeLa STAT-2JAK1, TYK211,900 ± 36513
CFU-E 3 U/ml EPOJAK212,000, 33002
CFU-E 0.3 U/ml EPOJAK27800, 27002