Percent inhibition, relative to vehicle-treated animals, of ankle diameter, paw weight, and histopathology scores for VX-509 q.d. dose experiments
Using ANOVA plus Dunnett’s (measures) and Kruskal-Wallis ANOVA (scored parameters) post hoc tests. n = 4 for control group, n = 8 for all treatment groups. Mean baseline values for the collagen + vehicle group are cumulative ankle diameter = 55.9 mm, paw weight = 2.1 g, ankle histopathology score = 11.4, knee histopathology score = 9.3. Control mean baseline values are cumulative ankle diameter = 45.7 mm, paw weight = 1.3 g, ankle histopathology score = 0, knee histopathology score = 0.
| Group | Dose | Dosing | Joint Measures, % Inhibition (±S.E.) | Histopathology Score, % Inhibition (±S.E.) | ||
|---|---|---|---|---|---|---|
| Ankle Diameter | Paw Weight | Ankle | Knee | |||
| mg/kg | ||||||
| Collagen + vehicle | — | q.d. | 0 (±7) | 0 (±5.5) | 0 (±12.5) | 0 (±12.9) |
| Collagen + VX-509 | 50 | q.d. | 58** (±7.3) | 71** (±9.4) | 62** (±16.9) | 94** (±3.5) |
| 100 | q.d. | 59** (±5.9) | 65** (±6) | 58** (±7) | 100** (±0) | |
| Collagen + etanercept | 10 | q.4.d. | 54** (±7) | 70** (±8.2) | 61** (±10.1) | 84** (±10.9) |
| Control | — | — | 100** | 100** | 100** | 100** |
↵** P < 0.01 compared with CIA rats in the vehicle group.