Pharmacokinetic parameters of MDMA and bupropion and metabolites
Values are mean ± S.E.M. in 16 healthy subjects.
| Cmax (ng/ml) | AUC0–8 | AUC0–24 | t1/2 | Tmax | |
|---|---|---|---|---|---|
| ng/ml⋅h | h | ||||
| MDMA | |||||
| Placebo–MDMA | 231 ± 14 | 1262 ± 72 | 2576 ± 156 | 7.4 ± 0.4 | 2.5 ± 0.2 |
| Bupropion–MDMA | 264 ± 13** | 1535 ± 67*** | 3428 ± 144*** | 9.2 ± 0.7** | 3.1 ± 0.2 |
| MDA | |||||
| Placebo–MDMA | 10.3 ± 0.5 | 59.2 ± 3.1 | 170 ± 11 | 6.1 ± 0.3 | |
| Bupropion–MDMA | 8.8 ± 0.5** | 46.8 ± 2.7*** | 149 ± 8.5 | 6.8 ± 0.3 | |
| HMMA | |||||
| Placebo–MDMA | 123 ± 22 | 711.2 ± 99 | 1482 ± 247 | 8.5 ± 0.5 | 3.5 ± 0.3 |
| Bupropion–MDMA | 29.6 ± 3.3*** | 169 ± 18*** | 492 ± 54*** | 15.1 ± 1.1*** | 6.0 ± 0.3*** |
| Bupropion | |||||
| Bupropion–placebo | 93.2 ± 7.5 | 486 ± 36 | 1030 ± 69 | 10.3 ± 0.9 | 5.1 ± 0.5 |
| Bupropion–MDMA | 110 ± 8.3# | 615 ± 40### | 1313 ± 84## | 8.7 ± 0.8 | 5.8 ± 0.4 |
| Hydroxybupropion | |||||
| Hydroxybupropion–placebo | 748 ± 63 | 4976 ± 337 | 14490 ± 1273 | 7.3 ± 0.6 | |
| Hydroxybupropion–MDMA | 793 ± 62 | 5613 ± 486 | 16056 ± 1336 | 7.1 ± 0.6 | |
| Hydrobupropion | |||||
| Hydrobupropion–placebo | 37.4 ± 2.1 | 267 ± 18 | 769 ± 51 | 7.0 ± 0.6 | |
| Hydrobupropion–MDMA | 40.9 ± 2.0# | 287 ± 17 | 822 ± 47 | 7.7 ± 0.5 | |
↵** P < 0.01; ***P < 0.001 compared with placebo–MDMA; #P < 0.05; ##P < 0.01; ###P < 0.001 compared with bupropion–placebo.