TABLE 2

Ki values from the inhibition of rosuvastatin uptake through OATP1A2 by different tricyclic compounds

The values in parentheses represent the 95% confidence interval (see also Supplemental Fig. 3).

CompoundKi
µM
Amitriptyline3.7 (2.9–4.6)
Carazolol3.2 (2.2–4.1)
Carvedilol1.1 (0.9–1.3)
Chlorpromazine5.3 (4.4–6.1)
Clomipramine3.3 (2.7–3.9)
Desipramine8.4 (6.7–10.0)
Doxepin4.7 (3.6–5.8)
Imipramine3.5 (2.5–4.5)
Nortriptyline12.0 (9.0–15.0)
Trimipramine2.8 (2.1–3.5)