TABLE 1

IC50 values from the inhibition of rosuvastatin uptake through OATP1A2 by different tricyclic compounds

The values in parentheses represent the 95% confidence interval (see also Supplemental Fig. 2).

CompoundIC50
µM
Amitriptyline11.7 (9.1–15.0)
Carazolol3.7 (2.9–4.8)
Carvedilol3.2 (2.7–3.9)
Chlorpromazine12.0 (7.5–19.2)
Clomipramine8.2 (5.2–13.0)
Desipramine37.0 (22.3–61.4)
Doxepin12.1 (7.1–20.6)
Imipramine16.9 (13.2–21.6)
Nortriptyline25.0 (13.2–47.6)
Trimipramine15.0 (8.1–27.8)
CarbamazepineNo effect
CarbazoleNo effect
PhenothiazineNo effect