TABLE 1
Cytotoxicity (IC
50
) of SKI-178 versus vincristine and colchicine
AML Cell Line
SKI-178
Vincristine
Colchicine
nM
HL-60
472 ± 2.95
2.3 ± 0.016
9.5 ± 0.034
HL-60/VCR
1057 ± 3.06
2280 ± 9.3
583 ± 2.6
THP-1
686.7 ± 1.98
NA
NA
U-937
885.4 ± 1.98
NA
NA
NA, not available.