TABLE 1

Cytotoxicity (IC50) of SKI-178 versus vincristine and colchicine

AML Cell LineSKI-178VincristineColchicine
nM
HL-60472 ± 2.952.3 ± 0.0169.5 ± 0.034
HL-60/VCR1057 ± 3.062280 ± 9.3583 ± 2.6
THP-1686.7 ± 1.98NANA
U-937885.4 ± 1.98NANA
  • NA, not available.