Pharmacokinetic Parameter | Memantine Dose | ||
---|---|---|---|
3 mg/kg | 5 mg/kg | 10 mg/kg | |
Memantine plasma concentration (ng/ml) | |||
0.25 hours | 84 ± 31 | 189 ± 76 | 735 ± 247 |
0.5 hours | 140 ± 25 | 234 ± 51 | 555 ± 162 |
1 hour | 161 ± 20 | 213 ± 23 | 520 ± 113 |
2 hours | 138 ± 12 | 192 ± 31 | 428 ± 53 |
4 hours | 81 ± 6 | 134 ± 25 | 316 ± 33 |
8 hours | 41 ± 13 | 67 ± 14 | 184 ± 29 |
24 hours | 5 ± 4 | 6 ± 4 | 34 ± 12 |
Cmax (ng/ml) | 176 ± 17 | 290 ± 57 | 817 ± 213 |
Tmax (h) | 1 ± 0.22 | 0.83 ± 0.27 | 1.29 ± 0.61 |
t1/2 (h) | 4.76 ± 1.42 | 4.23 ± 0.72 | 6.29 ± 0.8 |