TABLE 1

The cytotoxicity of PAT is directed toward endothelial cells

Data are presented as growth inhibition of HUVECs, a panel of NSCLC cells, and normal lung fibroblast cells by PAT as determined by MTS assay.

Cell LineIC50 Value
μM
Human endothelial cells
 HUVECs (EGM-2)4.32
 HUVECs (VEGF)7.55
 HUVECs (bFGF)6.05
Human lung fibroblast cells
 WI-38>100
 MRC-549.72
Human lung cancer cells
 A549>100
 NCI-H441>100
 NCI-H46042.72
 PC972.52
 NCI-H52244.68
 NCI-H66167.87