Compound | IC50 ± S.E.M. | Chemical Class |
---|---|---|
nM | ||
(+)-Butaclamol | 260 ± 32 | DR antagonist |
Amitriptyline | 5.1 ± 1.2 | TCA |
Amoxapine | 20 ± 8.4 | TeCA |
Atomoxetine | No inhibitiona | NRI |
Clomipramine | 56 ± 18 | TCA |
Desipramine | 3300 ± 600 | TCA |
Doxepin | 20 ± 6.2 | TCA |
Fluoxetine | No inhibitiona | SSRI |
Fluvoxamine | No inhibitiona | SSRI |
Imipramine | 360 ± 34 | TCA |
Norclomipramine | 670 ± 35 | TCA |
Nortriptyline | 140 ± 50 | TCA |
Protriptyline | 600 ± 250 | TCA |
SCH-23390 | 1300 ± 340 | D1DR antagonist |
Trazodone | No inhibitiona | SARI |
Venlafaxine | No inhibitiona | SNRI |
D1DR, selective D1-like dopamine receptor antagonist; DR antagonist, nonselective dopamine receptor antagonist; NRI, norepinephrine reuptake inhibitor; SARI, serotonin antagonist and reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant; TeCA, tetracyclic antidepressant.
↵a Less than 10% inhibition at 3 µM compound.