TABLE 1

EC₅₀ and area under the curve (AUC) values for vanillin, vanillyl alcohol, and ethyl vanillin concentration response curves measured in porcine coronary artery rings contracted with U46619 (2 × 10⁻⁷ M), 40 mM KCl, and endothelin-1 (2 × 10⁻⁸ M), and basilar artery segments contracted with U46619 (10⁻⁷ M)

Data are expressed as mean ± S.E.M.

Contraction	Vanillin		Vanillyl Alcohol		Ethyl Vanillin
Contraction	−log(EC₅₀)	AUC	−log(EC₅₀)	AUC	−log(EC₅₀)	AUC
U46619 (n = 8–10) coronary artery	3.31 ± 0.06	154.9 ± 14.9	2.49 ± 0.10^*	73.5 ± 6.4^*	4.03 ± 0.07^*	223.5 ± 8.6^*
U46619 (n = 8) basilar artery	2.77 ± 0.15	118.9 ± 7.9	2.22 ± 0.29^*	81.5 ± 11.5^*	3.16 ± 0.16	145.4 ± 10.9
40 mM KCl (n = 8–9) coronary artery	3.26 ± 0.03	151.2 ± 5.2	3.20 ± 0.07	148.6 ± 6.7	3.49 ± 0.04^*	173.9 ± 3.4^*
Endothelin-1 (n = 10–11) coronary artery	3.64 ± 0.09	206.5 ± 12.2	3.30 ± 0.10^*	170.9 ± 9.1^*	4.13 ± 0.07^*	253.0 ± 8.5^*

↵* Statistically significant difference (P < 0.05) from vanillin group.