EC50 and area under the curve (AUC) and values for vanillin, vanillyl alcohol, and ethyl vanillin concentration response curves of porcine coronary artery rings contracted with U46619 (2 × 10−7 M) and preincubated with various antioxidants
Data are expressed as mean ± S.E.M.
| Vanillin | Vanillyl Alcohol | Ethyl Vanillin | ||||
|---|---|---|---|---|---|---|
| −log(EC50) | AUC | −log(EC50) | AUC | −log(EC50) | AUC | |
| Control (n = 8) | 3.10 ± 0.06 | 142.4 ± 7.3 | 2.77 ± 0.12 | 135.9 ± 25.3 | 3.67 ± 0.03 | 184.4 ± 3.0 |
| +1 mM tempol | 3.12 ± 0.08 | 144.4 ± 5.8 | 2.70 ± 0.12 | 117.6 ± 15.7 | 3.84 ± 0.06 | 224.5 ± 10.1* |
| +1 mM N-acetyl-l-cysteine | 3.22 ± 0.09 | 151.5 ± 9.2 | 3.02 ± 0.19 | 131.6 ± 17.9 | 3.75 ± 0.08 | 202.4 ± 10.2 |
| +1 mM tiron | 3.28 ± 0.12 | 176.7 ± 13.5 | 3.30 ± 0.27 | 174.8 ± 22.3 | 3.88 ± 0.07 | 206.5 ± 6.4 |
| Control (n = 8) | 3.19 ± 0.08 | 141.7 ± 9.7 | 2.69 ± 0.11 | 112.6 ± 3.8 | 3.79 ± 0.11 | 201.9 ± 6.6 |
| +100 µM apocynin | 3.31 ± 0.06 | 165.6 ± 8.2 | 3.27 ± 0.26 | 176.6 ± 27.1* | 3.98 ± 0.26 | 219.2 ± 25.4 |
| Control (n = 9) | 3.33 ± 0.14 | 164.8 ± 16.5 | 2.81 ± 0.10 | 113.5 ± 7.4 | 3.76 ± 0.03 | 191.5 ± 2.5 |
| +1000 U/ml catalase | 3.18 ± 0.06 | 148.2 ± 8.4 | 2.75 ± 0.10 | 117.5 ± 12.2 | 3.71 ± 0.11 | 187.8 ± 11.8 |
↵* Statistically significant difference (P < 0.05) from control.