TABLE 1

Gene methylation involved in organ fibrosis

GeneCells/TissuesDiseasesConsequenceReference(s)
HypermethylationRasal1Renal fibroblasts and HSCPatients and mice with kidney fibrosis; rats with hepatic fibrosisDownregulationBechtel et al., 2010; Tao et al., 2011
FLI1Dermal fibroblastsPatients with systemic sclerosisDownregulationWang et al., 2006
E-cadherinBronchial epithelial cellsCell lineDownregulationWu et al., 2012
PTGER2Pulmonary fibroblastsIPF patients, and mice with lung fibrosisDownregulationHuang et al., 2010b
Thy-1Lung tissuesPatients with IPFDownregulationSanders et al., 2008
Smad4Lung tissuesPatients with IPFDownregulationTakenaka et al., 2009
p14Pulmonary fibroblastsPatients with IPFDownregulationCisneros et al., 2012
PTENHSCRats with hepatic fibrosisDownregulationBian et al., 2012
PPARγHSCRats with hepatic fibrosisDownregulationMann et al., 2010
SOCS1Liver tissueMice with hepatic fibrosisDownregulationYoshida et al., 2004
SOCS3Liver tissueHuman and mice with hepatic fibrosisDownregulationOgata et al., 2006
HypomethylationSPP1Liver tissueMice with hepatic fibrosisUpregulationKomatsu et al., 2012
STK17B, HIST1H2AHLung tissueIPF patientsUpregulationRabinovich et al., 2012

  • HSC, hepatic stellate cell; SPP1, secreted phosphoprotein 1.