TABLE 1
Biologic activity of tocopherol and flavonoid derivatives on myoblast cells survival
C2C12 myoblast cells were cultured for 48 hours in presence of the indicated compounds. Cell survival was evaluated using MTT test.
| Derivative | Compound | Formula | IC50 for Cytotoxicity | Concentration for Maximum Survival | Maximum Survival |
|---|---|---|---|---|---|
| µM | % of control | ||||
| Flavanoid | AGT031 |  | 10–25 | 0.5 | 105 |
| AGT171 |  | 75–125 | 0.5 | 103 | |
| AGT184 |  | 25–50 | 0.5 | 102 | |
| AGT216 |  | 10–25 | 0.5 | 103 | |
| Tocopherol | AGT048 |  | 50–75 | 25 | 122 |
| AGT251 |  | 50–75 | 12.5 | 141 | |
| AGT072 |  | 50–75 | 0.5 | 100 | |