TABLE 2

ADP (5 µM)-induced aggregation of platelets isolated from male healthy volunteers

Slope represents the rate of platelet aggregation during time. Maximum aggregation curves are the percentage of aggregation in the samples containing the molecule under evaluation, with respect to ADP alone, on the primary and secondary wave of aggregation, respectively.

	Slope	Maximum Aggregation
	Slope	First Curve	Second Curve
		%
Control	38 ± 2	55 ± 3	85 ± 4
HPipNONO
10 μM	52 ± 3	65 ± 3	81 ± 7
30 μM	31 ± 2	30 ± 2**	8 ± 1**
Ni(PipNONO)Cl
1 μM	48 ± 5	60 ± 4	75 ± 4
10 μM	20 ± 2**	14 ± 1**	1 ± 0.5**
DETA/NO
1 μM	49 ± 4	55 ± 3	80 ± 3
10 μM	47 ± 3	52 ± 3	61 ± 4
30 μM	40 ± 2	43 ± 4^*	8 ± 2**

↵* P < 0.05 and **P < 0.01 versus control.