TABLE 3

Plasma measurement of inflammatory and oxidative stress markers from DS rats on a HF/HS diet following 4 weeks of treatment with vehicle control, the ET_A receptor antagonist, ABT-627, and/or the diuretic, CLTD

	Control	ABT	CLTD	ABT + CLTD
TNF-α (pg/ml)	0.105 ± 0.001	0.103 ± 0.001	0.105 ± 0.005	0.098 ± 0.002
TNF-R1 (pg/ml)	943 ± 169	536 ± 64	538 ± 128	412 ± 35^*
TNF-R2 (pg/ml)	1571 ± 119	1254 ± 50	1155 ± 175	975 ± 79^*
8-OHdG (ng/ml)	3.6 ± 0.8	1.5 ± 0.2^*	2.1 ± 0.2	1.6 ± 0.2^*

↵* P < 0.05 versus control.