TABLE 1

Inhibitory effects of canagliflozin on SGLT2 and SGLT1

IC50 values are expressed as means ± S.E.M.

IC50
SGLT2SGLT1IC50 Ratio of 
SGLT1/SGLT2
nnM
Human44.2 ± 1.5663 ± 180158
Rat33.7 ± 0.2555 ± 31150
Mouse35.6 ± 1.1613 ± 56109