TABLE 3

Inhibitory effect of canagliflozin on GLUTs in rat skeletal muscle myoblasts, HepG2 cells, human primary adipocytes, and CHO cells expressing human GLUT5

IC50 values are expressed as means ± S.E.M.

Cell TypeIC50
μM
Rat skeletal muscle myoblast (expressing GLUT1)>10
HepG2 cells (expressing GLUT1 and GLUT2)>50
Human primary adipocytes (with insulin)6.8 ± 1.5
CHO cells expressing human GLUT5>20