In vitro 11β-HSD1 inhibitory activity of HIS-388
Potency of test substance against human (h) and mouse (m) 11β-HSD1 was determined using liver microsomes and expressed as IC50. The values are means of at least two determinations.
| Compound | Liver MS IC50 | |
|---|---|---|
| hHSD1 | mHSD1 | |
| nmol/l | ||
| HIS-388 | 14.7 | 82.0 |
| CBX | 550 | 115 |
| Cpd544 | 20.9 | 269 |