Pharmacodynamic parameter estimates of PF06463922 for ALK phosphorylation in nonclinical tumor models after twice daily repeated oral administration
Precision of the estimates is expressed as standard error in parentheses.
| Model | EC50 | E0 | Emax | kout | kmd | γ | OFV |
|---|---|---|---|---|---|---|---|
| ng/ml | h−1 | ||||||
| IDR | 137 | 1 | 1 | 4.8 | na | 0.95 | −262 |
| (18) | (fixed) | (fixed) | (1.7) | (0.08) | |||
| PCS | 58 | 1 | 1 | 1.8 | 0.021 | 1.1 | −284 |
| (14) | (fixed) | (fixed) | (0.4) | (0.003) | (0.1) | ||
E0, ALK phosphorylation baseline; IDR, indirect response model; kmd, first-order degradation rate constant for a modulator; kout, first-order degradation rate constant; na, not applicable; PCS, precursor model.