Pharmacokinetic parameter estimates of PF06463922 in nonclinical tumor models after twice daily oral administration
Precision of the estimates is expressed as standard error in parentheses.
| Study | Dose | CL/F | V/F | ka | OFV |
|---|---|---|---|---|---|
| mg/kg | l/h per kg | l/kg | h−1 | ||
| 1 | 0.3–10 | 1.2 | 5.3 | 2.0 | 543 |
| (0.1) | (0.8) | (0.6) | |||
| 2 | 0.3–20 | 1.1 | 7.0 | 1.3 | 802 |
| (0.2) | (0.9) | (0.1) | |||
| 3 | 0.01–3 | 1.7 | 11 | 4.0 | 275 |
| (0.1) | (1) | (2.2) |