TABLE 2

Binding affinities for cloned human receptors in vitro

Data are calculated by nonlinear regression analysis using data from three assays performed in duplicate or triplicate and expressed as mean values.

Human Receptor	Binding Affinity (K_i)
Human Receptor	Brexpiprazole	Aripiprazole	Bifeprunox	Risperidone
		nM
hD_2L	0.30	0.87	0.41	1.9
hD₃	1.1	1.6	0.63	13
h5-HT_1A	0.12	1.3	0.73	420^{^a}
h5-HT_2A	0.47	4.7	NT	0.22
h5-HT_2B	1.9	0.36^{^b}	NT	35^{^c}
hα_1B-adrenergic	0.17	35^{^b}	NT	9^{^d}
hα_2C-adrenergic	0.59	38^{^b}	NT	9.1^{^a}
hH₁	19	18	NT	27^{^a}
hM₁	67% at 10 µM	6780^{^b}	NT	>10,000^{^d}

NT, not tested.
↵a Data from Schotte et al., 1996.
↵b Data from Shapiro et al., 2003.
↵c Data from Kroeze et al., 2003.
↵d PDSP certified data (http://pdsp.med.unc.edu/pdsp).