TABLE 1

Overview of effects in rat test models of positive psychotic symptoms of schizophrenia and CNS side effects

Results are expressed as ED₅₀ values (milligram per kilogram) with 95% CI. Drug pretreatment times are shown in parentheses with exceptions in footnotes.

Effect	No. in Group	ED₅₀
Effect	No. in Group	Brexpiprazole (1 h)^{^a}	Aripiprazole (2 h)^{^b}	Risperidone (1 h)^{^c}
		mg/kg p.o. (95% CI)
Efficacy tests
CAR	4–6	6.0 (4.3–9.7)	23 (20–27)	3.3 (2.0–7.6)
APO hyperactivity (0.25 mg/kg)	5	2.3 (1.2–3.1)	3.2 (1.9–5.0)	NT
APO stereotypy (0.7 mg/kg)	6	2.9 (2.2–3.8)	6.1 (5.2–7.2)	4.7 (2.9–6.9)
AMPH hyperactivity (0.5 mg/kg)	8	0.92 (0.6–1.5)	3.9 (2.0–7.7)	NT
CNS side effects
Inhibition of spontaneous locomotor activity	8	3.4 (2.4–5.0)	6.1 (2.3–16)	NT
Catalepsy (at time of maximum effect)	6	20 (12–40)	42 (26–68)	6.6 (2.9–16)

AMPH, amphetamine; APO, apomorphine; NT, not tested.
↵^a Except for spontaneous locomotor activity, amphetamine-induced hyperactivity (2 hours) and catalepsy (maximum effect at 6 hours).
↵^b Except for catalepsy (maximum effect at 8 hours).
↵^c Except for catalepsy (2 hours).