Potency of tanshinone II A sulfonate to modulate different biologic activities
| Biologic Activity | Assay | IC50 | Reference |
|---|---|---|---|
| µM | |||
| Human P2X7 | Ca2+ influx | 4.3 | This study |
| Mouse P2X7 | Ca2+ influx | >50 | This study |
| Rat P2X7 | Ca2+ influx | >50 | This study |
| Human P2X4 | Ca2+ influx | >50 | This study |
| Rat P2X2 | Ca2+ influx | 35 | This study |
| Vasodilation of rat mesenterial arteries | Myography | 40 | Liu et al., 2009 |
| BKCa channels | Increased channel activity | 68.5 | Tan et al., 2011 |
| Human carboxylesterase 2 | Degradation of o-nitrophenyl acetate and irinotecan, respectively | 3.9, 28.8 | Hatfield et al., 2013 |