Biologic Activity | Assay | IC50 | Reference |
---|---|---|---|
µM | |||
Human P2X7 | Ca2+ influx | 4.3 | This study |
Mouse P2X7 | Ca2+ influx | >50 | This study |
Rat P2X7 | Ca2+ influx | >50 | This study |
Human P2X4 | Ca2+ influx | >50 | This study |
Rat P2X2 | Ca2+ influx | 35 | This study |
Vasodilation of rat mesenterial arteries | Myography | 40 | Liu et al., 2009 |
BKCa channels | Increased channel activity | 68.5 | Tan et al., 2011 |
Human carboxylesterase 2 | Degradation of o-nitrophenyl acetate and irinotecan, respectively | 3.9, 28.8 | Hatfield et al., 2013 |