Plasma exposures of brexpiprazole and aripiprazole in rat NOR studies
See Figs. 1–3. The results show mean ± S.E.M. plasma concentrations from groups of six rats, measured after completion of NOR test. Blood samples were taken approximately 3 hours after drug administration.
| Treatment (Dose) | Plasma Concentration | ||
|---|---|---|---|
| Experiment 1 | Experiment 2 | Experiment 3 | |
| mg/kg p.o. | ng/ml ± S.E.M. | ||
| Brexpiprazole | |||
| 0.3 | 11 ± 1.3 | — | — |
| 1.0 | 31 ± 2.7 | — | — |
| 3.0 | 113 ± 36 | 74 ± 7.9 | 89 ± 10 |
| Aripiprazole | |||
| 10 | 40 ± 1.5 | — | — |
| 20 | — | 158 ± 29 | — |