TABLE 1

Measured concentrations of ADX88178 in mice and rats at the end of experiments

Treatment	Species	Route	Dose	n	Mean Plasma Exposure
			mg/kg		ng/ml
EPM^{^a}
ADX88178	Mice	p.o.	1	10	10
ADX88178	Mice	p.o.	3	10	229
ADX88178	Mice	p.o.	10	10	1287
ADX88178	Mice	p.o.	30	10	2865
ADX88178	Rats	p.o.	10	10	1129
ADX88178	Rats	p.o.	30	10	2295
ADX88178	Rats	p.o.	100	10	3513
MB^{^b}
ADX88178	Mice	p.o.	3	10	22
ADX88178	Mice	p.o.	10	10	541
ADX88178	Mice	p.o.	30	10	1619
ADX88178	Mice	p.o.	100	10	4395
FST^{^c}
ADX88178	Mice	p.o.	3	10	167
ADX88178	Mice	p.o.	10	10	1776
ADX88178	Mice	p.o.	30	10	2994
ADX88178	Mice	p.o.	100	10	6028
DOI^{^d}
ADX88178	Mice	p.o.	3	8	33
ADX88178	Mice	p.o.	10	8	338
ADX88178	Mice	p.o.	30	8	1146
MK-801^{^e}
ADX88178	Mice	p.o.	3	10	23
ADX88178	Mice	p.o.	10	10	133
ADX88178	Mice	p.o.	30	10	624
CAR^{^f}
ADX88178	Rats	p.o.	1	8	106
ADX88178	Rats	p.o.	3	8	408
ADX88178	Rats	p.o.	10	8	1273
ADX88178	Rats	p.o.	30	8	3030

↵^a Plasma sample taken from all ADX88178-treated animals approximately 65 minutes postadministration.
↵^b Plasma sample taken from all ADX88178-treated animals approximately 90 minutes postadministration.
↵^c Plasma sample taken from all ADX88178-treated animals approximately 66 minutes postadministration.
↵^d Plasma sample taken from all ADX88178-treated animals approximately 66 minutes postadministration.
↵^e Plasma sample taken from all ADX88178-treated animals approximately 120 minutes postadministration.
↵^f Plasma sample taken from all ADX88178-treated animals approximately 70 minutes postadministration.