TABLE 1

Effects α7 nAChR

CompoundDrug AlonePlus PNU-120596a
ImaxEC50IC50Normalized Response
µM
tetMA1.06 ± 0.0330 ± 396 ± 28
EtriMA>4>30041 ± 8
diEdiMA0.9 ± 0.0131 ± 155 ± 10
triEMA0.15 ± .01107 ± 4368 ± 11
TEA80 ± 55.6 ± 2.5
Choline1.1 ± 0.1270 ± 3023 ± 7
(2OHE)-EdiMA1.5 ± 0.31500 ± 300173 ± 50
(2OHE)-diEMA>10,00024 ± 9
BtriMA0.47 ± 0.0239 ± 538 ± 20
BEdiMA67 ± 227 ± 8
BdiEMA42 ± 425 ± 12
BtriEA26 ± 10.18 ± 0.07
diMPyrr1.0 ± 0.118 ± 316 ± 3
EMPyrr0.9 ± 0.150 ± 146 ± 11
diEPyrr0.38 ± 0.03180 ± 33350 ± 10024 ± 6
diMPip0.8 ± 0.124 ± 249 ± 10
EMPip350 ± 10031 ± 4
diEPip200 ± 705.1 ± 1.9
diMHHA0.29 ± 0.01183 ± 715 ± 3.5
EMHHA159 ± 360.14 ± 0.06
diEHHA40 ± 80.23 ± 0.15
  • a Data for choline and related compounds were obtained at 1 mM plus 10 µM PNU-120596; data for all other compounds were obtained at 100 µM plus 10 µM PNU-120596. Values are for net charge relative to responses evoked by 60 µM ACh applied alone to the same cells.