A selection of in vivo data alluding to potential utility for curcumin in tertiary lung cancer chemoprevention strategies
| Year | Model | Observations | Reference |
|---|---|---|---|
| 2013 | Female C57 mice bearing LL/2 cell xenograft | A novel formulation of curcumin/doxorubicin-loaded methoxy poly(ethyleneglycol) (MEG)-PCL nanoparticles (i.v. every 5 days for 15 days) had greater antitumor and apoptosis-inducing efficacy than either agent alone. | Wang et al., 2013a |
| 2013 | Female nude mice bearing A549 xenograft | Solid lipid nanoparticle curcumin (SLN) and native curcumin (200 mg/kg i.p. daily for 19 days) exhibited 32-fold higher levels in lung than native curcumin, and decreased tumor growth by >3-fold compared with native curcumin. | Wang et al., 2013b |
| 2013 | Female nude mice bearing A549 xenograft | Curcumin (500 mg/kg per day) given in conjunction with phospho-sulindac synergistically inhibits tumor growth and improves bioavailability of phospho-sulindac in xenograft tissue. | Cheng et al., 2013 |
| 2013 | Female Balb/c-nu mice bearing A549 xenograft | Curcumin analog 4-arylidene curcumin (1 and 5 mg/kg i.p. once every 5 days for 20 days) significantly decreased tumor growth, reactivated p53, and inhibited NFκB signaling. | Zhou et al., 2013b |
| 2013 | C57BL/6 mice with TNFα aspirated into lungs | Curumin nanoparticles (200 mg/kg i.p. prior to TNFα) decreased ICAM-1 expression in lung alveolar epithelial cells. | Yen et al., 2013 |
| 2013 | Nude mice bearing A549 xenograft | Curcumin nanoparticles (15 mg/kg) decreased tumor growth to a greater extent than nonformulated curcumin. | Yin et al., 2013b |
| 2012 | Male C57BL.6 with tracheal instillation of LLC cells | Curcumin-cyclodextrin complex (3 mg/kg) potentiates the effects of gemcitabine to significantly decrease tumor volume and proliferative index (Ki67). | Rocks et al., 2012 |
| 2012 | C57BL/6J mice bearing LL/2 xenografts | Liposomal curcumin (5 mg/kg per day for 14 days) enhanced antitumor activity of radiation dose delivered to the thorax. Curcumin decreased the onset of radiation pneumonitis and enhanced tumor response in combination with radiation. | Shi et al., 2012 |
| 2012 | Nude mice bearing A549 xenograft | Curcumin (15 mg/kg i.v.) synergistically enhanced the antitumor efficacy of docetaxel. | Yin et al., 2012 |
| 2011 | VEGF-overexpressing transgenic mice | Curcumin (5 mg/kg i.p. three times weekly for 5 months) decreased pulmonary function damage, decreased pulmonary inflammation, and decreased mRNA levels of vegrf, kdr, nrp-1, c-myc, egfr, erk2, and cyclin a. | Tung et al., 2011 |
| 2010 | Female C57BL/6 mice with tracheal instillation of LLC cells | Curcumin (1% or 5% in diet) prevented pulmonary fibrosis following thoracic irradiation (13.5 Gy), but did not enhance antitumor efficacy of radiation. | Lee et al., 2010 |
| 2010 | Balb/cnu/nu mice bearing NCI-H460 xenografts | Curcumin (30 or 45 mg/kg per day i.p.) inhibits tumor growth. | Su et al., 2010 |
ICAM-1, intracellular adhesion molecule-1; kdr, kinase insert domain receptor; NFκB, nuclear factor κB; nrp, neuropilin; PCL, poly-ε-caprolactone; TNFα, tumor necrosis factor α; VEGF, vascular endothelial growth factor.