Test Model (Receptor) | Brexpiprazole | Aripiprazole | ||
---|---|---|---|---|
ED25 or ED50 (95% CI) | Maximum response (Mean ± S.E.M.) | ED25 or ED50 (95% CI) | Maximum response (Mean ± S.E.M.) | |
mg/kg | % | mg/kg | % | |
Reserpine-induced DOPA accumulation (D2) | 4.4 (2.3–8.0)a | 55 ± 3.7 | 3.7 (2.2–5.9)a | 89 ± 2.4 |
DOI-induced head twitches (5-HT2A) | 4.7 (3.2–6.6)b | 99 ± 0.9 | 21 (7.2–47)b | 91 ± 3.6 |