TABLE 4 Reconstructed and estimated in vivo Kp,uu,brain values of the six compounds in cynomolgus monkeys
The reconstructed Kp,uu,brain values were calculated as the reciprocals of the reconstructed Kp,brain ratios (see Table 2) using eq. 5. The in vivo Kp,uu,brain values were estimated from the fu,plasma and fu,brain (homogenate + pH partition model) values and the observed Kp,brain values in cynomolgus monkeys (see Tables 1 and 3) using eq. 4. Each value represents the mean ± S.E.M. The S.E.M. was calculated according to the law of propagation of error.