Effects of quinpirole on ICSS responding in minutes 0–15 after injection
All data are the mean percentage of preinjection baseline (± S.E.M.).
| Dose | ||||||
|---|---|---|---|---|---|---|
| VEH | 0.1 | 0.3 | 0.56 | 1.0 | 3.0 | |
| mg/kg | ||||||
| BSR threshold | ||||||
| C57 | 111 ± 3.8 | 140 ± 11 | 174 ± 19* | 144 ± 10 | 155 ± 12* | 162 ± 5.6* |
| DBA | 115 ± 5.3 | 96.6 ± 9.4 | 160 ± 17* | 144 ± 21 | 159 ± 13* | 137 ± 13 |
| MAX response rate | ||||||
| C57 | 79.6 ± 3.8 | 59.0 ± 7.6 | 66.7 ± 3.7 | 60.0 ± 12 | 49.6 ± 5.2* | 28.7 ± 2.8* |
| DBA | 86.5 ± 3.0 | 112 ± 8.6† | 62.8 ± 8.6 | 45.5 ± 6.9 | 31.9 ± 6.6* | 29.7 ± 10.2* |