TABLE 1

LX4211 inhibits SGLT-mediated glucose transport

SpeciesSGLT1SGLT2
IC50NIC50N
nMnM
Humana36 ± 991.8 ± 0.48
Mouseb62 ± 2680.6 ± 0.28
Rat104 ± 38110.5 ± 0.310
Dog86 ± 1481.4 ± 0.58

  • IC50, concentration causing half-maximal inhibition; N, number of determinations.

  • ↵a Data are from Zambrowicz et al., 2012.

  • ↵b Data are from Powell et al., 2013b.