TABLE 3

Pharmacokinetic parameters after a 3 or 10 mg/kg oral dose of LX4211

SpeciesNDoseHalf-LifeTmaxCmaxAUC0–∞%F
mg/kghhnMnM*h
Dog537.38 ± 1.170.65 ± 0.342502 ± 32518775 ± 413271 ± 16
Rat410ND3.00 ± 1.151116 ± 378NDND
Mouse4106.52 ± 0.820.31 ± 0.134373 ± 40819079 ± 158098 ± 8
  • %F, % bioavailable; N, number of animals; ND, not determined.