TABLE 1

Patients dosed with diclofenac

The complete lists of comedications are recorded in Supplemental Table 3. A blank entry signifies that none of the comedications is known to form an AG metabolite in humans.

PatientDiclofenac Doses and FormulationsaBlood Sampling after Last Diclofenac DoseComedications Metabolized to AG in Humansb
hrs
N01 (male, 42 yr)50 mg, b.i.d. (EC)1
N02 (female, 65 yr)50 mg, b.i.d. (EC)1
N03 (female, 52 yr)50/75 mg AM/PM (EC/MR)1
N08 (male, 63 yr)50 mg, t.i.d. (EC)3aspirin, ramipril rosuvastatin
N09 (male, 48 yr)50 mg, t.i.d. (EC)2.5simvastatin
N10 (female, 77 yr)50 mg, t.i.d. (Voltarol dispersible tablets)2.5

  • EC, enteric-coated; MR, modified release.

  • ↵a Diclofenac sodium formulations except where indicated. All the patients had taken diclofenac for at least 1 year.

  • ↵b AG metabolites of comedications are formed in vivo and/or in vitro.