TABLE 2

Pharmacokinetic parameters after a 1 mg/kg i.v. dose of LX4211

SpeciesNHalf-LifeAUC0–∞CLVss
hnM*hml/min/kgl/kg
Dog57.27 ± 1.398849 ± 17964.6 ± 0.91.98 ± 0.34
Rat40.90 ± 0.091847 ± 13221.3 ± 1.51.40 ± 0.07
Mouse41.39 ± 0.451940 ± 33120.6 ± 3.02.07 ± 0.14
  • CL, clearance; N, number of animals; Vss, volume at steady state.