TABLE 2

Effect of κ antagonism on the hepatotoxicity of thiobenzamide

Condition	Alkaline Phosphatase^a	SGPT (ALT)	SGOT (AST)	Albumin	BUN
Control	227.3 ± 13.8	44.7 ± 8.7	82.3 ± 27.6	2.9 ± 0.1	23.3 ± 3.2
Thiobenzamide alone	150.5 ± 55.6^*	798 ± 447.1^*	1021 ± 775.8^*	2.6 ± 0.3	66.2 ± 34.9^*
Thiobenzamide + compound 5	122.5 ± 18.8	613.7 ± 349.2^**	993 ± 172.2	2.8 ± 0.4	43.2 ± 7.4
Thiobenzamide + naltrexone	169 ± 84.5	1749.8 ± 245.1^***	1461.8 ± 312.3	2.5 ± 0.2	57.8 ± 23.9

ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen.
↵^a Mean ± S.D. of values from six animals.
↵* P < 0.05 for control versus thiobenzamide (274 mg/kg) alone.
↵** P < 0.05 for thiobenzamide (274 mg/kg) alone versus thiobenzamide + naltrexone (500 µg/kg).
↵*** P < 0.05 for thiobenzamide (274 mg/kg) + compound 5 (20 µg/kg) versus thiobenzamide (274 mg/kg) + naltrexone (500 µg/kg).