Physicochemical properties in aqueous solution of OCA, INT-777, INT-767, and their corresponding natural BA analogs
| Ws | CMC | STCMC | log P(A−) | pKa | Albumin Binding | |
|---|---|---|---|---|---|---|
| µM | mM | Dyne/cm | % | |||
| CDCA | 32 | 3.2 | 45.5 | 2.2 | 5 | 96 |
| OCA | 9 | 2.9 | 48.8 | 2.5 | 5 | 96 |
| CA | 273 | 9.0 | 49 | 1.1 | 5 | 88 |
| INT-777 | 99 | 2.0 | 50.1 | 1.4 | 5 | 62 |
| TCDCA | Hs | 3.0 | 47.1 | 0.9 | <1 | 70 |
| INT-767 | Hs | 1.3 | 47.9 | 2.0 | <1 | 85 |
CMC, critical micellar concentration; Hs, highly soluble; log P(A−), octanol/water partition coefficient; pKa, acid dissociation constant; STCMC, surface tension at CMC; Ws, water solubility.