Kinase-selectivity profile of SOMG-833
IC50 values are shown as the mean ± S.D. or estimated values from three separate experiments.
| Tyrosine Kinase | IC50 | Tyrosine Kinase | IC50 |
|---|---|---|---|
| nM | nM | ||
| c-MET | 0.93 ± 0.15 | RET | >10,000 |
| RON | >10,000 | EGFR | >10,000 |
| Axl | >10,000 | ErbB2 | >10,000 |
| Tyro-3 | >10,000 | ErbB4 | >10,000 |
| ALK | >10,000 | c-Src | >10,000 |
| Flt-1 | >10,000 | ABL | >10,000 |
| KDR | >10,000 | EPH-A2 | >10,000 |
| c-Kit | >10,000 | EPH-B2 | >10,000 |
| PDGFRα | >10,000 | IGF1R | >10,000 |
| PDGFRβ | >10,000 | FGFR1 | >10,000 |
ABL, Abelson murine leukemia viral oncogene homolog 1; Axl, tyrosine-protein kinase receptor UFO; c-Kit, tyrosine-protein kinase kit; c-Src, tyrosine-protein kinase CSK; EGFR, epidermal growth factor receptor; EPH, Ephrin-type receptor; ErbB2 (HER2), human epidermal growth factor receptor 2; ErbB3, human epidermal growth factor receptor 3; FGFR1, fibroblast growth factor receptor 1; Flt-1, vascular endothelial growth factor receptor 1; IGF1R1, insulin-like growth factor 1; VEGFR2, vascular endothelial growth factor receptor 2; PDGFR, platelet-derived growth factor receptor; RET, rearranged during transfection tyrosine kinase; RON, macrophage-stimulating protein receptor; Tyro-3, tyrosine-protein kinase receptor.