Parameter | 160 µg/kg i.v. Cebranopadol |
---|---|
C0 (ng/ml) | 22.8 ± 1.01 |
AUC (h × ng/ml) | 22.2 ± 3.73 |
t1/2,z (hours) | 4.52 ± 0.82 |
CL (l/kg/h) | 7.37 ± 1.38 |
Vz (l/kg) | 47.1 ± 5.34 |
C0, extrapolated concentration at the time of intravenous bolus administration (t = 0 hours); AUC, area under the plasma concentration-time curve extrapolated to infinity; t1/2,z, terminal half-life; CL, total clearance; Vz, apparent volume of distribution during the terminal phase of disposition.