TABLE 1

The effect of PG490-88 on cytokines in cisplatin-induced AKI

Vehicle (N = 9)Vehicle + PG (N = 7)Cisplatin (N = 18)Cisplatin + PG (N = 16)
IL-1β (pg/g)964 ± 131872 ± 2456421 ± 2506*7032 ± 2392*
IL-1α (pg/g)78 ± 3453 ± 501943 ± 953*1985 ± 839*
IL-6 (pg/g)1133 ± 1171078 ± 2025342 ± 1953*5080 ± 2118*
CXCL1 (pg/g)2111 ± 15081590 ± 50363,650 ± 19,111*64,760 ± 19,878*
IL-33 (pg/mg)193 ± 15169 ± 36271 ± 75*297 ± 48*
TNF-α (pg/g)820 ± 43760 ± 67750 ± 120780 ± 103
  • PG, PG490-88.

  • * P < 0.001 versus vehicle.