TABLE 1
Growth inhibitory percentages of UC compounds
Data are shown as mean ± S.E.M. Compounds were tested at a concentration of 3 or 10 µM (MTS assay, n = 4) and IC50 (µM) values of compounds were compared with embelin against cancer cell proliferation (sulforhodamine B assay, n = 4).
| Compound ID | UC-274 | UC-476 | UC-112 | UC-222 | Embelin | ||
|---|---|---|---|---|---|---|---|
 |  |  |  |  | |||
| µM | |||||||
| Growth inhibition (%) | A375 | 3 | 12.8 ± 3.5 | 16.7 ± 2.3 | 50.7 ± 5.1 | 67.0 ± 1.6 | N.D. |
| 10 | 73.7 ± 2.4 | 84.0 ± 1.6 | 65.0 ± 3.4 | 94.6 ± 1.0 | N.D. | ||
| M14 | 3 | 39.9 ± 3.3 | 20.6 ± 2.0 | 81.1 ± 1.7 | 73.7 ± 2.0 | N.D. | |
| 10 | 70.2 ± 1.1 | 85.3 ± 3.8 | 99.6 ± 0.6 | 99.2 ± 0.7 | N.D. | ||
| IC50 (µM) | A375 | 13.4 ± 0.7 | 10.4 ± 0.2 | 1.6 ± 0.1 | 2.7 ± 0.4 | 14.3 ± 3.2 | |
| M14 | 12.3 ± 0.4 | 10.2 ± 0.2 | 2.5 ± 0.3 | 3.5 ± 0.1 | 20.7 ± 5.4 | ||
| PC-3 | 15.1 ± 0.3 | 12.8 ± 2.1 | 0.7 ± 0.1 | 2.3 ± 0.2 | 13.0 ± 1.8 | ||
| DU145 | 17.3 ± 2.9 | 11.4 ± 2.2 | 3.4 ± 0.8 | 4.5 ± 1.7 | 23.2 ± 3.7 | ||
| Average* | 14.5 ± 1.1 | 11.2 ± 0.6 | 2.1 ± 0.6 | 3.3 ± 0.5 | 17.8 ± 2.5 | ||
N.D., not determined.
↵* Average IC50 value was calculated using the data across all four tested cell lines of the same compound.