ED50 values for phenyltropanes in decreasing rates of responding maintained by cocaine injection (0.32 mg/kg per injection) or food presentation (three pellets/presentation)
ED50 values reported in milligram per kilogram with 95% confidence limits in parentheses.
| Treatment | Cocaine | Food Presentation | Relative Potency |
|---|---|---|---|
| RTI-336 | 3.92 (3.42–4.53) | 10.9 (6.77–24.5) | 0.255* (0.101–0.510) |
| RTI-371 | 3.33 (3.06–3.63) | 8.21 (5.30–15.6) | 0.377 (0.181–0.703) |
↵* Value is only an estimate as there were significant effects of preparations and a significant deviation from parallel.