TABLE 1

Pharmacology of (+) and (−)-MBP at human (h) and mouse (m) 5-HT₂ receptors

K_i values (nM) were determined by displacement of [³H]5-HT (agonist labeled), [³H]ketanserin (5-HT_2A), or [³H]mesulergine (5-HT_2B, 5-HT_2C) (antagonist labeled). Function values were determined by an inositol phosphate hydrolysis assay that measured the 5-HT₂-mediated activation of phospholipase C. The pA₂ value was determined from competitive antagonism functional assays with 5-HT. All data were from HEK cells transiently expressing one of the three 5-HT₂ receptors. Data represent the mean (± S.E.M.) from at least three independent experiments.