TABLE 2

Tyrosine kinase inhibition of nintedanib in a cellular BA/F3 assay

To compare the cellular activity of nintedanib on specific tyrosine kinase receptors, it was tested at 10–1000 nM in BA/F3 cells engineered to be proliferation-dependent on a single tyrosine kinase. IC50 values for nintedanib to inhibit cell proliferation dependent on specific tyrosine kinases are listed in nanomoles.

AssayIC50
nM
FGFR1300–1000
FGFR2257
FGFR3300–1000
FGFR4300–1000
PDGFRα41
PDGFRβ58
VEGFR1300–1000
VEGFR246
VEGFR333
LCK22
LYN300–1000
SRC811
FLT-317