TABLE 1

Ki, EC50, and pA2 values for JNJ-39758979 at histamine receptors from various species

ReceptorSpeciesKiaEC50pA2a
nMμM
H4Human12.5 ± 2.6>107.9 ± 0.1
H4Mouse5.3 ± 0.4>108.3 ± 0.2
H4Rat188 ± 61>107.2 ± 0.2
H4Monkey25 ± 1>107.5 ± 0.1
H4Guinea pig306 ± 23NDND
H4Dog>10,000NDND
H3Human1043 ± 348NDND
H3Mouse202 ± 29NDND
H3Rat258 ± 26NDND
H2Human>1000NDND
H1Human>1000NDND
H1Mouse6800 ± 1800NDND
H1Monkey>10,000NDND
  • ND, not determined.

  • a Data given as ± S.E.M. if the assay was run at least twice.