Maximal responses (Emax) and potency (pEC50) values derived from concentration–response curves to tadalafil (0.0001–10 μM) and 8-Br-cGMP (0.003–100 μM) in urethra smooth muscle from lean and obese mice.
Data are presented as mean ± S.E.M. (n = 5–8). Values of Emax are represented as percentage.
| Group | Tadalafil | 8-Br-cGMP | ||
|---|---|---|---|---|
| Emax | pEC50 | Emax | pEC50 | |
| % | % | |||
| Lean | 51.2 ± 7.6 | 8.68 ± 0.19 | 55.3 ± 3.9 | 5.78 ± 0.08 |
| Obese | 50.2 ± 4.2 | 8.62 ± 0.13 | 49.9 ± 2.4 | 5.62 ± 0.05 |