TABLE 1

Strongest differentially regulated genes comparing AAV6-shB1 versus AAV6-shCTR–treated EHTs

Left column specifies downregulated genes (FC < 0.58) and right column upregulated genes (FC > 1.74).

Downregulated Genes	FC	Upregulated Genes	FC
Tissue factor pathway inhibitor 2	0.24	Angiopoetin 2	2.76
RT1 class II, locus Da	0.25	Mitochondrial ribosomal protein L18	2.36
RT1 class II, locus Ba	0.32	Iroquois homeobox 5	2.34
RT1 class II, locus Db1	0.37	Sodium channel, type IV, β	2.05
Oxidized low density lipoprotein receptor 1	0.26	Glycerol-3-phosphate-dehydrogenase 1	1.96
Serine peptidase inhibitor1, clade E	0.3	Calcium channel, T type, α_1G subunit	1.96
Apolipoprotein C-I	0.37	LIM domain binding 3	1.94
Cd74 molecule	0.37	Adrenergic, α_1B-, receptor	1.92
Interleukin 1 receptor antagonist	0.39	Leucine-rich repeat-containing 10	1.86
B-cell leukemia 2–related protein A1d	0.41	Iroquois homeobox 4	1.84
Regulator of G-protein signaling 2	0.41	Gap junction protein, α₅	1.82
Actin, α₁, skeletal muscle	0.47	Cbp/p300-interacting transactivator	1.81
C-type lectin domain family 4, member e	0.48	G-protein-coupled receptor 56	1.8
Nuclear factor, interleukin 3–regulated	0.48	Carbonic anhydrase 9	1.79
Natriuretic peptide precursor A	0.49	Phospholipase A₂, group V	1.77
ATP-binding cassette, subfamily A1	0.52	Proprotein convertase subtilisin/kexin type 6	1.77
Hypoxia-inducible factor 1, α subunit	0.52	GATA-binding protein 5	1.75
Interleukin 18	0.52	Fibroblast growth factor 16	1.73
Ribonucleotide reductase M2	0.57
Tropomyosin 4	0.58