Doses of nicotine alone and after pretreatment with DHβE, varenicline, or (−)-cytisine that are calculated to produce 50% responding on the MA-associated lever (ED50 values with 95% confidence intervals) and relative potencies of nicotine after pretreatment (ED50 nicotine/ED50 nicotine after pretreatment)
Data were obtained in squirrel monkeys trained to discriminate intramuscular injections of 0.1 mg/kg (0.67 μmol/kg) MA from saline.
| Pretreatment Drug | Doses | ED50 | Relative Potency |
|---|---|---|---|
| mg/kg | mg/kg (95% CI) (μmol/kg) | ||
| Nicotine alone | 0.01–0.32 | 0.03 (0.02–0.05) (0.20) | 1 |
| DHβE | 0.032 | 0.39 (0.19–1.90) (2.39) | 0.08 (0.03–0.20) |
| 0.1 | 0.30 (0.12–2.76) (1.85) | 0.11 (0.03–0.27) | |
| Varenicline | 0.0032 | 0.39 (0.19–2.55) (2.40) | 0.09 (0.02–0.23) |
| 0.032 | 0.75 (0.45–1.69) (4.63)a | 0.06 (0.01–0.14) | |
| 0.1 | 0.53 (0.26–3.02) (3.25)a | 0.07 (0.02–0.16)a | |
| (−)-Cytisine | 0.032 | 0.23 (-0.19–0.02)b (1.39) | 0.13 (0.03–0.36) |
| 0.1 | 0.44 (0–0.13)b (2.72) | 0.08 (0.02–0.23) |